PROGRAM IN
Cellular & Molecular Medicine
Featured Publications
2026
Jun, 2026
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms
Fu TM, Liu G, Milkie DE, Ruan X, Gorlitz F, Shi Y, Ferro V, Divekar NS, Wang W, York HM, Kilic V, Mueller M, Liang Y, Daugird TA, Jose Gacha-Garay M, Larkin KA, Adikes RC, Harrison N, Shirazinejad C, Williams S, Nourse JL, Sheu SH, Gao L, Li T, Mondal C, Achour K, Hercule W, Stabley DR, Emmerich K, Dong P, Drubin DG, Liu ZJ, Mumm JS, Koyama M, Killilea AN, Javier Bravo-Cordero J, Dirk Keene C, Luo L, Kirchhausen T, Pathak MM, Arumugam S, Nunez JK, Gao R, Matus DQ, Martin BL, Swinburne IA, Betzig E, Legant WR, Upadhyayula S.
Jun, 2026
Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model
Tian M, Davis J, Cheng H, Thompson LM, Tuchel M, Williams AC, Yin A, Wilder B, DiBiase I, Seaman MS, Alt FW.
May, 2026
Linear RAG scanning mediates editing of Igκ variable region repertoires
Li X, Hu H, Zhang Y, Zhu T, Guan Y, Xu K, Lin X, Hebert C, Batra H, Zhou J, Ba Z, Wesemann DR, Ye AY, Alt FW.
May 12, 2026
Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation
Saha G, Anchi P, Wang R, Biondo A, Meyer S, Kondragunta V, Luchsinger LL, Syed I, Sharif H, Wu H, Giri Magupalli V.
May 12, 2026
How endosomal PIKfyve inhibition prevents viral membrane fusion and entry
Chow N, Scanavachi G, Saminathan A, Kirchhausen T.
Apr, 2026
Light-guided molecular patterning for high-throughput single-molecule mechanical characterization
Choi H, Ward A, Wong WP.
Mar 31, 2026
Batra H, Luo S, Saunders KO, Higgins JS, Jian F, Zhang J, Kibria MG, Jonaid GM, Zhou QJ, Eaton A, Cronin K, Mallory ML, Mattocks M, Edwards RJ, Parks R, Lee EM, Ye AY, Williams AC, Jung G, Mansouri K, Alam SM, Montefiori DC, Tian M, Baric RS, Cao Y, Haynes BF, Chen B, Alt FW.
Mar 27, 2026
Wang J, Wu M, Magupalli VG, Dahlberg PD, Wu H, Jensen GJ.
Mar 11, 2026
Xu RJ, Cadinu P, Nicol PB, Herrmann US, Lee T, Geistlinger L, Irizarry RA, Moffitt JR.
Mar, 2026
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
Tesfamariam YM, Christensen MH, Diehl S, Klein T, Lingnau JM, Normann S, Hagelauer E, Herbert M, Reimer S, Joshi RP, Engels P, Pritzl S, Fontana P, Zillinger T, Hartmann G, Eis-Hübinger A, Lam MC, Walgenbach KJ, Meissner F, Wu H, Schmidt FI.
Jan 5, 2026
Single-molecule mechanostructural fingerprinting of nucleic acid conformations
Shrestha P, Bergal HT, Shih WM, Wong WP.
Jan 5, 2026
Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM
Nair, A. Nair, A. Stock, P. Jain, A. Somerville, E. Sanyal, A. Costa-Filho, J. I. Kirchhausen, T.
2025
Dec 15, 2025
Fare, C M., Rhine, K., Lam, A., Myong, S., Shorter, J.
Dec 4, 2025
Cohesin drives chromosome scanning during the RAD51-mediated homology search
Marin-Gonzalez A, Rybczynski A, Nilavar N, Nguyen N, Li A, Karwacki-Neisius V, Zou RS, Aviles-Vazquez F, Kanemaki M, Scully R, Ha T.
Dec 2, 2025
Zhang Y, Watson B, Rattan A, Lee T, Chawla S, Gestlinger G, Guan Y, Ma M, Caldarone BJ, Song W, Moffitt JR, Carroll MC.
Nov 14, 2025
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model
Zhu Y-D, Maurer DP, Castrillon C, Deng Y, Mohamed AN, Ma M, Tang D, Min-Debartolo J, Higgison-Scott N, Buhlmann J, Schmidt AG, Lingwood D, Carroll MC.
Nov 12, 2025
FUS nanoclusters are a distinct state within the dilute phase
Ge Y, Paul T, Gordiychuk M, Das N, Zhang Y, Myong S.
Oct 28, 2025
de Lau WBM, Wijnakker JJAPM, van Son GJF, Krueger D, Wang D, Abendroth MS, Schreurs R, Janda CY, van Rijt FLH, Chalopin BJP, Bokobza E, van Es JH, Springer TA, Sonnenberg A, Clevers H.
Sep 23, 2025
Opposing roles of two R-loop associated G-quadruplexes in tuning transcription activity
Yang L, Lee CY, Paul T, Myong S.
Aug 31, 2025
Protocol optimization improves the performance of multiplexed RNA imaging
Luce JJ, Reardon-Lochbaum CA, Cadinu P, Xu RJ, Aceves-Salvador J, Semizoglou E, Wong B, Lopez I, Cantor AB, Renthal W, Moffitt JR.
Aug 26, 2025
Probing the dynamic strength of biomolecular interactions with single-cell centrifugation
Bergal, HT, Kinoshita, K, Wong, WP.
Aug 26, 2025
ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
Bai Y, Zhang C, Liu H, Deng F, Wu Z, Deng Z, Zheng Z, Min R, Mei S, Kang H, Yu H, Pan Y, Lieberman J*, Zhao J* and Liu X*.
Aug, 2025
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
Sun N, Lin C-H, Li MY, Wang Y, Chen D, Ren X, Zhang F, Zhang Y.
Jul, 2025
Nanobodies targeting EGFR provide insight into conformations stabilized by glioblastoma mutations
Watson SM, Harvey EP, Pishesha N, Ploegh HL, Springer TA.
Jun 20, 2025
Lee H, Rashid F, Hwang J, London JA, Fishel R, Berger JM, Myong S, Ha T.
May 8, 2025
Kaestel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Da Cunha Correia RFB, Nielsen AJ, Bleshoy SV, Tsolakidis K, Boomsma W, Kirchhausen T, Hatzakis NS.
May 7, 2025
Native nucleosomes intrinsically encode genome organization principles
Park S, Merino-Urteaga R, Karwacki-Neisius V, Carrizo GE, Athreya A, Marin-Gonzalez A, Benning NA, Park J, Mitchener MM, Bhanu NV, Garcia BA, Zhang B, Muir TW, Pearce EL, Ha T.
Apr 17, 2025
Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites
Leng F, Merino-Urteaga R, Wang X, Zhang W, Ha T, Hur S.
Apr 9, 2025
Hwang J, Lee CY, Brahmachari S, Tripathi S, Paul T, Lee H, Craig A, Ha T, Myong S.
Apr 8, 2025
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
Ahmad S, Zou T, Hwang J, Zhao L, Wang X, Davydenko A, Buchumenski I, Zhuang P, Fishbein AR, Capcha-Rodriguez D, Orgel A, Levanon EY, Myong S, Chou J, Meyerson M, Hur S.
Mar 20, 2025
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution
Hsu AY, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, Balasubramanian A, Xie X, Yu H, Loison F, Haridas V, Zha J, Liu F, Park SY, Bagale K, Ren Q, Fan Y, Zheng Y, Cancelas JA, Chai L, Stowell SR, Chen K, Xu R, Wang X, Xu Y, Zhang L, Cheng T, Ma F, Thiagarajah JR, Wu H, Feng S, Luo HR.
Mar, 2025
Cadinu P, Yang E, Xu RJ, Watson BR, Luce J, Moffitt JR.
Mar, 2025
CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data
Costa-Filho JI, Theveny L, de Sautu M, Kirchhausen T.
Feb 25, 2025
Wu EJ, Kandalkar AT, Ehrmann JF, Tong AB, Zhang J, Cong Q, Wu H.
Feb 3, 2025
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs
Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Bango Da Cunha Correia RF, Aylan B, Sitarska E, Oikonomou A, Hatzakis NS, Kirchhausen T.
Jan, 2025
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Wang Y, Zhang W, Zhang C, Van HT, Seino T, Zhang Y.
Jan, 2025
The transcription factor GABPA is a master regulator of naïve pluripotency
Zhou C, Wang M, Zhang C, Zhang Y.
Jan 24, 2025
Highly multiplexed spatial transcriptomics in bacteria
Sarfatis A, Wang Y, Twumasi-Ankrah N, Moffitt JR.
Jan 14, 2025
Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B.
Jan 2, 2025
Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution
Watson BR, Paul B, Rahman RU, Amir-Zilberstein L, Segerstople A, Epstein ET, Murphy S, Geistlinger L, Lee T, Shih A, Deguine J, Xavier RJ, Moffitt JR, Mullen AC.