PROGRAM IN
Cellular & Molecular Medicine
Research Highlights
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Clinical connections desired: access to human Tonsillar GC B cells and potentially Peyer’s Patch GC B cells
Michael Carroll: B cell escape of tolerance; mechanisms underlying schizophrenia; complement and neuroinflammation; mitochondrial metabolism and BBB leakage.
Clinical connections desired: autoimmunity and neuroscience
Anne Goldfeld: TNF locus transcriptional regulation, immunity to human TB and HIV/TB co-infection
Clinical connections desired: regulation and pathogenesis of TNF in autoimmunity and infection; host directed treatment of TB and TB/HIV in human disease and primary cell models
Taekjip (TJ) Ha: Genome maintenance, chromatin biophysics and mechanobiology.
Clinical connections desired: learning about metabolic disorders, collaborations on variants of unknown significance, repeat expansion disorders.
Sun Hur: Molecular mechanism of foreign nucleic acid sensing and transcriptional regulation of the immune system.
Clinical connection desired: autoimmunity, autoinflammation.
Tom Kirchhausen: organelle biogenesis and membrane trafficking, intracellular delivery routes for biologics, and amyloid propagation through cells and tissues.
Clinical connection desired: Develop CNS-penetrant small molecules to block pathogenic endolysosomal aggregate seeding relevant for Parkinson’s, Alzheimer’s, and ALS.
Julia Li: Role of viral DNA sequences in shaping the human genome
Judy Lieberman: innate immunity and T cell and NK immunity to infection and cancer; development of RNA and small molecule therapeutics to modify inflammation and induce cancer immunity.
Clinical connection desired: clinical samples for our studies of cancer immunology and long COVID.
Jeff Moffitt: Novel genome-scale imaging methods for understanding host-microbe interactions
Clinical connections desired: more clinical connections in gastrointestinal disease (building on our collaboration with Scott Snapper on IBD) and infection
Sua Myong: Single molecule detection of protein-nucleic acid interaction, biomolecular condensation;
Clinical Connection: RNA binding protein aggregation implicated in Neurodegenerative diseases (ALS, FTLD), molecular mechanism of Cancers
Tim Springer: Signaling between cells and their environments, including through integrins, TGF-beta and growth factors, that regulates cell development and localization.
Clinical connections desired: Creating synthetic scaffolds for organoids and repair and regeneration of tissues.
Denisa Wagner: Molecular and cellular biology of thromboinflammation and animal models of inflammation spread by neutrophils
Clinical connections desired: pathology
Wesley Wong: Physical interactions of biomolecules under mechanical stress, and the development of nanoscale and single-molecule methods.
Clinical Connections desired: High-sensitivity biomarker detection and proteomics for diagnostics; bleeding disorders such as von Willebrand disease.
Hao Wu: Structure and function of innate immune and inflammatory signaling complexes
Yi Zhang: Chromatin mediated transcriptional regulation in stem cells reprograming, embryonic development, brain reward and aging.
Clinical connections desired: Schizophrenia, Down syndrome, Alzheimer Disease and Substance abuse.