Scientific Advisory Board
Arlene Sharpe, MD, PhD
Kolokotrones University Professor, Harvard University
Chair of the Department of Immunology, Harvard Medical School
Member, Department of Pathology at Brigham and Women’s Hospital and the Broad Institute of MIT and Harvard
Leader, Cancer Immunology Program at Dana-Farber/Harvard Cancer Center
Vice Director, Gene Lay Institute of Immunology and Inflammation
Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School
Arlene Sharpe, MD, PhD
Dr. Sharpe earned her MD and PhD from Harvard Medical School and completed her residency in Pathology at Brigham and Women’s Hospital. A leader in T cell costimulation, her laboratory discovered and elucidated functions of T cell costimulatory pathways, including immunoinhibitory functions of the CTLA-4 and PD- 1 pathways, which laid the foundation for immune checkpoint blockade therapy in cancer. Today her laboratory investigates the roles of T cell costimulatory pathways in regulating T cell tolerance, antimicrobial and antitumor immunity, and translating this understanding into therapies for autoimmune diseases and cancer.
Dr. Sharpe has published over 400 papers and was listed by Thomson Reuters/Clarivate as one of the most Highly Cited Researchers (top 1%) in 2014-2023 and a 2016 Citation Laureate. Dr. Sharpe is an elected member of the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences as well as a Fellow of the American Association for Cancer Research, National Academy of Inventors, the Society for Immunotherapy of Cancer, and the American Association of Immunologists.